Genova's SIBO Profiles are non-invasive breath tests which capture exhaled hydrogen (H2) and methane (CH4) gases following patient ingestion of a Lactulose Rx solution to evaluate small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgrowth (IMO).

Clinicians have the option of a 2 or 3-hour SIBO assessment. The 3-hour SIBO profile provides insight into gas levels over a longer time frame and is recommended for patients with slower gastrointestinal transit or constipation. Additionally, a flatline result in the third hour could indicate the presence of hydrogen sulfide gas.

SIBO is a common clinical condition characterized by excessive bacteria in the small intestine and can develop in a variety of patient populations.

Symptoms and conditions commonly associated with SIBO include:

Bloating/distension
Gas
Diarrhea
Constipation
Abdominal pain
Dyspepsia
Irritable Bowel Syndrome (IBS)
Inflammatory Bowel Disease (IBD)
Celiac Disease
Diabetes
Fibromyalgia
Rosacea
Parkinson's Disease
Obesity

Risk factors for development of SIBO include:

Intestinal motility disorders
Chronic pancreatitis
Abdominal structural/anatomic issues
Gastroenteritis
Immunocompromise
Decreased bacteriostatic digestive secretions (HCl, pancreatic enzymes, bile acids) such as with PPI use
Ileocecal valve dysfunction

If left untreated, SIBO can lead to complications such as malabsorption and intestinal permeability, or leaky gut.

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